This study proposes PROS, an efficient pattern-driven compressive sensing framework for low-power biopotential-based wearables. PROS eliminates the conventional trade-off between signal quality, response time, and power consumption by introducing tiny pattern recognition primitives and a pattern-driven compressive sensing technique that exploits the sparsity of biosignals. Specifically, we (i) develop tiny machine learning models to eliminate irrelevant biosignal patterns, (ii) efficiently perform compressive sampling of relevant biosignals with appropriate sparse wavelet domains, and (iii) optimize hardware and OS operations to push processing efficiency. PROS also provides an abstraction layer, so the application only needs to care about detected relevant biosignal patterns without knowing the optimizations underneath..